科研之友
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摘要
Purpose: We aimed to investigate the effects of either local application of aminoguanidine to oral mucosal wound or systemic administration application of aminoguanidine on the oxidant and anti-oxidant parameters of wound tissue and plasma.
Materials and Methods: New-Zealand rabbits (n=18) were used in the study. A standard incision was applied to the oral mucosa of rabbits. Rabbits were divided into three groups as: Untreated incisional group (Group I), local polyethylene glycol + aminoguanidine (12.7 mg) bead (Group II), and subcutaneous aminoguanidine administrated group (100 mg/kg 3 day) (Group III). Oral wound tissue nitric oxide, malondialdehyde, and glutathione levels and plasma thiobarbituric acid reactive substances, nitric oxide and total sulfhydryl group levels were measured.
Results: In histological analysis, a significant reepithelization in the wound region was seen in aminoguanidine treated rabbits. The rabbits in Group III had significantly increased fibroblasts and collagen fibers. Aminoguanidine administration significantly decreased the malondialdehyde and plasma thiobarbituric acid reactive substances levels of wounded-tissues (p<0.05). Although not significant, the glutathione levels of wounded tissues were increased in the aminoguanidine treated groups compared to non treated group (p>0.05). Plasma total sulfhydryl group levels were significantly increased after subcutaneous aminoguanidine administration (p<0.05).
Conclusion: In conclusion, our results suggested that subcutaneous/local administraiton of aminoguanidine might improve the wound healing by reducing the levels of oxidant products.
- 出版日期2011
