Diversity Oriented Approach to Polycyclic Compounds through the Diels-Alder Reaction and the Suzuki Coupling

作者：Kotha Sambasivarao^*; Misra Shilpi; Srinivas Venu

来源：European Journal of Organic Chemistry, 2012, (21): 4052-4062.

DOI：10.1002/ejoc.201200484

• Synthesis design
• Medicinal chemistry
• Drug discovery
• Template synthesis
• Cross-coupling

A diversity oriented strategy has been demonstrated to deliver small drug like molecules using alkylation, DielsAlder reaction, and SuzukiMiyaura cross-coupling as key steps. This methodology allows access a wide range of molecules using simple scaffolds such as indanes, tetralins and tetrahydroisoquinolines, which can enhance the chemical space for potential therapeutic molecules.

• 出版日期2012-7