Ivabradine HCL-Loaded Polymeric Microspheres Consisting of Ethyl Cellulose and Eudragit FS30D for Controlled Drug Release

作者：Majeed Abdul^*; Ranjha Nazar Muhammad

来源：Advances in Polymer Technology, 2018, 37(3): 21715.

DOI：10.1002/adv.21715

• Ethyl cellulose
• Eudragit FS30D
• Ivabradine HCL
• Microspheres

In this study, microspheres of Eudragit FS30D and ethyl cellulose (EC) were prepared by oil-in-oil (O/O) solvent evaporation method with the addition of 1% span 80 as emulsifier. Ivabradine HCl (IBH) was encapsulated into microspheres by the in situ method. The resultant microspheres were characterized with respect to drug loading, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and release behavior. Chemical stability of IBH encapsulated into prepared microspheres was confirmed by FTIR, DSC, and XRD analysis. SEM images showed spherical microspheres. Maximum percentage entrapment efficiency of ivabradine was found to be 45.1% and percentage yield was about 71.66%. Maximum in vitro drug release was 95.9% for the pH 7.5 buffer solution which demonstrated the pH sensitivity of microspheres. Cumulative drug release data were analyzed using different kinetic models. Korsmeyer-Peppas equation was used to determine the value of n which follows non-Fickian diffusion.

• 出版日期2018-4