Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis

作者：Turpeinen Anu M^*; Jarvenpaa Salme; Kautiainen Hannu; Korpela Riitta; Vapaatalo Heikki

来源：Annals of Medicine, 2013, 45(1): 51-56.

DOI：10.3109/07853890.2012.663926

• Antihypertensive effect
• bioactive peptides
• blood pressure
• IPP
• meta-analysis
• VPP

A meta-analysis of possible antihypertensive effects of small doses of bioactive tripeptides isoleucine-proline-proline and valine-proline-proline in commercial milk products or tablets was carried out. A random effects model was used on 19 randomized, placebo-controlled clinical intervention trials (published 1996-October 2010) consisting of about 1500 prehypertensive or mildly hypertensive subjects. The overall blood pressure lowering for systolic blood pressure was -4.0 mmHg (95% CI -5.9 to -2.1 mmHg, P < 0.001) and for diastolic blood pressure -1.9 mmHg (95% CI -3.1 to -0.8 mmHg, P < 0.001). However, a positive effect was not reported in all the studies. The results suggest that rather small daily doses of the lactotripeptides in different functional food products may off er a valuable option as a non-pharmacological treatment of prehypertension or mild hypertension as part of life-style advice.

• 出版日期2013-2