Molecular targets of curcumin for cancer therapy: an updated review

作者：Kasi Pandima Devi; Tamilselvam Rajavel; Skalicka Wozniak Krystyna; Nabavi Seyed Fazel; Daglia Maria; Bishayee Anupam; Pazoki toroudi Hamidreza; Nabavi Seyed Mohammad

来源：Tumor Biology, 2016, 37(10): 13017-13028.

DOI：10.1007/s13277-016-5183-y

• Anticancer
• Curcumin
• Polyphenol
• Turmeric

In recent years, natural edible products have been found to be important therapeutic agents for the treatment of chronic human diseases including cancer, cardiovascular disease, and neurodegeneration. Curcumin is a well-known diarylheptanoid constituent of turmeric which possesses anticancer effects under both pre-clinical and clinical conditions. Moreover, it is well known that the anticancer effects of curcumin are primarily due to the activation of apoptotic pathways in the cancer cells as well as inhibition of tumor microenvironments like inflammation, angiogenesis, and tumor metastasis. In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-beta catenin, mTOR and so on. Clinical studies also suggested that either curcumin alone or as combination with other drugs possess promising anticancer effect in cancer patients without causing any adverse effects. In this article, we critically review the available scientific evidence on the molecular targets of curcumin for the treatment of different types of cancer. In addition, we also discuss its chemistry, sources, bioavailability, and future research directions.

• 出版日期2016-10