DETERMINATION OF STABILITY CONSTANTS AND ACUTE TOXICITY OF POTENTIAL HEPATOTROPIC GADOLINIUM COMPLEXES

作者：Mikiciuk Olasik Elzbieta^*; Wojewoda Emilia; Bilichowski Ireneusz; Witczak Malgorzata; Karwowski Boleslaw; Wagrowska Danilewicz Malgorzata; Stasikowska Olga

来源：Acta Poloniae Pharmaceutica, 2010, 67(2): 119-127.

• gadolinium complexes
• hepatotropic contrast agents
• stability constants
• toxicity
• histopathology

Due to their high specificity or the hepatobiliary system, iminodiacetic acid derivatives are known to form a class of hepatobiliary agents. In this paper we present new hepatotropic gadolinium complexes to be used as potential MRI contrast agents. Derivatives of N-(2-phenylainine-2-oxoethyl)iminodiacetic acid are introduced as ligands into such complexes. In this way, we hope to achieve a valuable diagnostic tool for investigating of pathological chances in the liver. Stability constants of complexes were determined by potentiometric titration in 0.1 mol L(-1) NaNO(3) solution at 20.0 +/- 0.1 degrees C. Stability and selectivity constants were also determined for endogenous metal ions such as Cu(2+), Ca(2+), and Zn(2+) with the use of SUPERQUAD computer program. Acute toxicity of new gadolinium complexes was assessed in mice and histopathology examinations were carried out.

• 出版日期2010-4