A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers

作者:Yamaguchi Nonoka; Zouzumi Yu ki; Shimada Naohiko; Nakano Shu ichi; Sugimoto Naoki; Maruyama Atsushi*; Miyoshi Daisuke*
来源:Chemical communications, 2016, 52(47): 7446-7449.
DOI:10.1039/c6cc02237e

摘要

Although the B-form duplex is the canonical DNA structure, the A-form duplex plays critical roles in controlling gene expression. Here, reversible B-A transitions of DNA duplexes were induced by synthetic cationic and anionic polymers. Thermodynamic analysis demonstrated that the B-A transition was regulated by the dehydration of the DNA duplex caused by polymer binding.

  • 出版日期2016