All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection

作者：Mocanu Edgar^*; Shattock Richard; Barton David; Rogers Melissa; Conroy Ronan; Sheils Orla; Collins Claire; Martin Cara; Harrison Robert; O'Leary John

来源：Fertility and Sterility, 2010, 94(6): 2448-2450.

DOI：10.1016/j.fertnstert.2010.02.029

• CF mutation testing
• azoospermia
• male infertility
• oligozoospermia
• normozoospermia
• CFTR mutation incidence

We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males. (Fertil Steril (R) 2010;94:2448-50.

• 出版日期2010-11