Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development

作者：Judith Granados Lopez Angelica; Luis Ruiz Carrillo Jose; Steven Servin Gonzalez Luis; Luis Martinez Rodriguez Jose; Araceli Reyes Estrada Claudia; Gutierrez Hernandez Rosalinda; Adrian Lopez Jesus

来源：International Journal of Molecular Sciences, 2017, 18(2): 407.

DOI：10.3390/ijms18020407

• miRNA families
• strand 5p
• strand 3p
• cervical cancer

Aberrant miRNA expression is well recognized as a cancer hallmark, nevertheless miRNA function and expression does not always correlate in patients tissues and cell lines studies. In addition to this issue, miRNA strand usage conduces to increased cell signaling pathways modulation diversifying cellular processes regulation. In cervical cancer, 20 miRNA families are involved in carcinogenesis induction and development to this moment. These families have 5p and 3p strands with different nucleotide (nt) chain sizes. In general, mature 5p strands are larger: two miRNAs of 24 nt, 24 miRNAs of 23 nt, 35 miRNAs of 22 nt and three miRNAs of 21 nt. On the other hand, the 3p strands lengths observed are: seven miRNAs of 23 nt, 50 miRNAs of 22 nt, six miRNAs of 21 nt and four miRNAs of 20 nt. Based on the analysis of the 20 miRNA families associated with cervical cancer, 67 3p strands and 65 5p strands are selected suggesting selectivity and specificity mechanisms regulating cell processes like proliferation, apoptosis, migration, invasion, metabolism and Warburg effect. The insight reviewed here could be used in the miRNA based therapy, diagnosis and prognosis approaches.

• 出版日期2017-2