An Efficient Copper-Catalyzed Etherification of Aryl Halides

作者：Huang Jinkun^*; Chen Ying; Chan Johann; Ronk Mike L; Larsen Robert D; Faul Margaret M

来源：Synlett, 2011, (10): 1419-1422.

DOI：10.1055/s-0030-1260761

• ligand-free
• copper
• etherification
• aryl halides

An efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols has been developed. The key to the successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the corresponding alcohol as solvent.

• 出版日期2011-6