Beyond first-line HIV treatment regimens: the current state of antiretroviral regimens, viral load monitoring, and resistance testing in resource-limited settings

作者：Kumarasamy Nagalingeswaran^*; Krishnan Sheela

来源：Current Opinion in HIV and AIDS, 2013, 8(6): 586-590.

DOI：10.1097/COH.0000000000000004

• genotyping
• resource-limited settings
• second-line therapy
• third-line therapy
• viral load

Purpose of reviewWith the availability of antiretroviral drugs in resource-limited settings, there is a rapid scale-up of antiretroviral therapy in developing countries.Recent findingsThe review focuses on the issues faced while patients are on first-line antiretroviral therapy in the absence of viral load monitoring, and the availability and progress of the second-line antiretroviral drugs and the salvage regimens in resource-limited settings.SummaryThere is an urgent need for low-cost, low-tech viral load monitoring in resource-limited settings. Fixed-dose combination of antiretrovirals for first-line and second-line therapy will result in better effectiveness. There is a need for newer antiretroviral drugs in resource-limited settings.

• 出版日期2013-11