Diffuse fibrosis leads to a decrease in unipolar voltage: Validation in a swine model of premature ventricular contraction-induced cardiomyopathy

作者：Tanaka Yasuaki; Rahmutula Dolkun; Duggirala Srikant; Nazer Babak; Fang Qizhi; Olgin Jeffrey; Sievers Richard; Gerstenfeld Edward P^*

来源：Heart Rhythm, 2016, 13(2): 547-554.

DOI：10.1016/j.hrthm.2015.09.025

• Premature ventricular contraction
• Cardiomyopathy
• Fibrosis
• Electroanatomic mapping
• Voltage mapping

BACKGROUND Frequent premature ventricular contractions (PVCs) may lead to dilated cardiomyopathy. A leftward shift in the unipolar voltage distribution in patients with cardiomyopathy has also been described and attributed to increased fibrosis.
OBJECTIVES We established a swine model of PVC-induced cardiomyopathy and assessed (1) whether an increase in left ventricular fibrosis occurs and (2) whether increased fibrosis leads to a leftward shift in the unipolar voltage distribution.
METHODS Ten swine underwent implantation of ventricular pacemakers; 6 programmed to deliver a 50% PVC burden and 4 controls without pacing. Voltage maps were acquired at baseline and after 14 weeks of ventricular bigeminy.
RESULTS In the PVC group, left ventricular ejection fraction decreased from 67% +/- 7% to 44% +/- 15% (P < .05) with no change in controls (71% +/- 6% to 73% +/- 4%; P = .56). The fifth percentile of the bipolar and unipolar voltage distribution at baseline was 1.63 and 5.36 mV, respectively. In the control group, after 14 weeks of pacing there was no significant change in % bipolar voltage <1.5 mV (pre 1.2% vs post 2.2%; P = .34) or % unipolar voltage <5.5 mV (pre 4.0% vs post 3.5%; P = .20). In the PVC group, there was a significant increase in % unipolar voltage <5.5 mV (5.4% vs 12.6%; P < .01), with a leftward shift in the unipolar voltage distribution. Histologically, % fibrosis was increased in the PVC group (control 1.8% +/- 1.3% vs PVC 3.4% +/- 2.6%; P < .01).
CONCLUSION PVC-induced cardiomyopathy in swine leads to an increase in interstitial fibrosis and a leftward shift in the unipolar voltage distribution. These findings are consistent with findings in humans with PVC-induced cardiomyopathy.

• 出版日期2016-2