A novel manganese complex, Mn-(II) N-(2-hydroxy acetophenone) glycinate overcomes multidrug-resistance in cancer

作者：Ghosh Ruma Dey; Banerjee Kaushik; Das Satyajit; Ganguly Avishek; Chakraborty Paramita; Sarkar Avijit; Chatterjee Mitali; Choudhuri Soumitra K^*

来源：European Journal of Pharmaceutical Sciences, 2013, 49(4): 737-747.

DOI：10.1016/j.ejps.2013.05.002

• Manganese complex
• Multidrug resistance
• Apoptosis
• Leukemic cells
• Ehrlich ascites carcinoma

Multidrug resistance (MDR) remains a significant problem for effective cancer chemotherapy. In spite of considerable advances in drug discovery, most of the cancer cases still stay incurable because of resistance to chemotherapy. We synthesized a novel, Mn (II) complex (chelate), viz., manganese N-(2-hydroxy acetophenone) glycinate (MnNG) that exhibits considerable efficacy to overcome drug resistant cancer. The antiproliferative activity of MnNG was studied on doxorubicin resistant and sensitive human T lymphoblastic leukemia cells (CEM/ADR 5000 and CCRF/CEM). MnNG induced apoptosis significantly in CEM/ADR 5000 cells probably through generation of reactive oxygen species. Moreover, intraperitoneal (i:p.) application of MnNG at non-toxic doses caused significant increase in the life-span of Swiss albino mice bearing sensitive and doxorubicin resistant subline of Ehrlich ascites carcinoma cells.

• 出版日期2013-7-16