科研之友
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摘要
We report the synthesis of multifunctional FePt-Au hybrid nanoparticles via a simple hydrothermal approach and their potential application in cancer dual-modality MR/CT imaging diagnosis and simultaneous in situ therapy. After conjugation with meso-2,3-dimercaptosuccinic acid (DMSA) and SH-PEG-FA, the FePt-Au HNPs present high biostability in physiological solutions and successfully target folate acid (FA) receptor-positive cancer cells such as MCF-7, HeLa and HepG2. As a pH-sensitive agent, the as-prepared FePt-Au-DMSA/PEG-FA HNPs exhibit high cytotoxicity to the targeted cancer cells due to the generation of many reactive oxygen species (ROS) induced by the released Fe within the cells. The corresponding half-maximum inhibitory concentration value (IC50, Fe) is about 3.0 mu g mL(-1). MR images and CT scans in vitro and in vivo demonstrate that the HNPs hold great potential as a dual-modality MR/CT imaging contrast agent for high-accuracy early-stage diagnosis of cancer. In addition, in vivo antitumor and histological studies indicate that the tumor growth is significantly inhibited after treating with HNPs with no observable toxicity found in the other tissues. Therefore, the FePt-Au-DMSA/PEG-FA HNPs are a promising multifunctional nanotheranostic agent for dual-modality MR/CT imaging diagnosis and in situ cancer therapy.
