New alkamide and ent-kaurane diterpenoid derivatives from Senecio erechtitoides (Asteraceae)

作者：Ndom Jean C^*; Mbafor Joseph T; Meva'a Luc M; Kakam Zanestsie; Phanuel Arwa S; Ndongo Etienne; Harwood Laurence M; Mpondo Theophile N

来源：Phytochemistry Letters, 2010, 3(4): 201-206.

DOI：10.1016/j.phytol.2010.07.007

• Senecio erechtitoides
• Asteraceae
• Alkamides
• Kauranoids
• Antimicrobial activity

Fractionation of a MeOH/CH(2)Cl(2) (1/1) extract of the aerial parts of Senecio erechtitoides led to the isolation of six compounds including the hitherto unknown N-phenethylamide derivative named N-(p-hydroxyphenethyl)pentacosanamide (1), and a kauranoid derivative named derivative named ent-7-oxo-16 alpha,17-dihydroxykauran-19-oic acid (2), as well as four known compounds, ent-Kaur-16-en-19-oic acid (3), ent-7 beta-hydroxykaur-16-en-19-oic acid (4), ent-7-oxokaur-16-en-19-oic acid (5), steppogenin 4'-O-beta-D-glucoside (6). Their structures and relative configurations were elucidated on the basis of spectroscopic methods, chemical reactions, and comparison with previously known analogs. All isolates were evaluated for their antimicrobial activity and only diterpenoids were found to possess a potent inhibitor effect against the range of microorganism.

• 出版日期2010-12-17