Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

作者：Al Anazi Mashael R; Matou Nasri Sabine; Abdo Ayman A; Sanai Faisal M; Alkahtani Saad; Alarifi Saud; Alkahtane Abdullah A; Al Yahya Hamad; Ali Daoud; Alessia Mohammed S; Alshahrani Bushra; Al Ahdal Mohammed N; Al Qahtani Ahmed A

来源：Journal of Immunology Research, 2017, 2017: UNSP 1590653.

DOI：10.1155/2017/1590653

<jats:p>Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic, double-stranded RNAs. Thus, activation of TLR3 is a major factor in antiviral defense and tumor eradication. Although downregulation of<jats:italic> TLR3</jats:italic> gene expression has been mainly reported in patients infected with hepatitis C virus (HCV), the influence of TLR3 genotype on the risk of HCV infection, HCV-related cirrhosis, and/or hepatocellular carcinoma (HCC) remains to be determined. Single-nucleotide polymorphisms (SNPs) within the<jats:italic> TLR3 </jats:italic>gene and their associations with HCV-related disease risk were investigated in a Saudi Arabian population in this study. Eight<jats:italic> TLR3 </jats:italic>SNPs were analyzed in 563 patients with HCV, which consisted of 437 patients with chronic HCV infections, 88 with HCV-induced liver cirrhosis, and 38 with HCC. A total of 599 healthy control subjects were recruited to the study. Among the eight<jats:italic> TLR3 </jats:italic>SNPs studied, the rs78726532 SNP was strongly associated with HCV infection when compared to that in healthy control subjects. The rs5743314 was also strongly associated with HCV-related liver disease progression (cirrhosis and HCC). In summary, these results indicate that distinct genetic variants of<jats:italic> TLR3 </jats:italic>SNPs are associated with HCV infection and HCV-mediated liver disease progression in the Saudi Arabian population.</jats:p>

• 出版日期2017
• 单位King Saud University; Alfaisal University