A substitution/dynamic kinetic resolution - Asymmetric transfer hydrogenation tandem process for preparation of stereocenters beta-hydroxy sulfones

作者：Hu, Xiaoying; Zhang, Kun; Chang, Fengwei; Liu, Rui^*; Liu, Guohua; Cheng, Tanyu^*

来源：Molecular Catalysis, 2018, 452: 271-276.

DOI：10.1016/j.mcat.2018.04.019

• Asymmetric transfer hydrogenation
• Dynamic kinetic resolution
• beta-Hydroxy sulfones
• alpha-Bromoindenones
• Tandem process

A noval method for the synthesis of optically active beta-hydroxy sulfones was developed. Through a substitution/dynamic kinetic resolution-asymmetric transfer hydrogenation, the presented method was based on one-pot enantioselective organic transformations of alpha-bromoindenones and sodium arylsulfinate. The protocol employed RuCl2[(S,S)-TsDPEN](mesitylene) as a catalyst, and sodium formate as a hydrogen source, affording various optically pure vicinal stereocenters beta-hydroxy sulfones in high yields with excellent enantioselectivities (up to 99%) and diastereomeric ratios (up to 99:1) under mild reaction conditions.

• 出版日期2018-6
• 单位上海师范大学