Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action

作者：Berdichevets I N^*; Tyazhelova T V; Shimshilashvili Kh R; Rogaev E I

来源：Biochemistry-Moscow, 2010, 75(9): 1088-1097.

DOI：10.1134/S0006297910090026

• lysophosphatidic acid
• LPA analogs
• autotaxin
• G protein-coupled receptors
• expression of human phospholipase genes

Lysophosphatidic acid (LPA) is a lipid mediator required for maintaining homeostasis of numerous physiological functions and also involved in development of some pathological processes through interactions with G protein-coupled receptors. Recently many data have appeared about the role of this phospholipid in humans, but pathways of LPA biosynthesis and mechanisms of its action remain unclear. This review presents modern concepts about biosynthesis, reception, and biological activity of LPA in humans. Natural and synthetic LPA analogs are considered in the view of their possible use in pharmacology as agonists and/or antagonists of G protein-coupled receptors of LPA.

• 出版日期2010-9