Driving Rel-iant Tregs toward an Identity Crisis

作者：Li Amy; Jacks Tyler^*

来源：Immunity, 2017, 47(3): 391-393.

DOI：10.1016/j.immuni.2017.08.014

Inhibiting Treg cell function in tumors is an attractive strategy to improve anti-cancer immunity. In a pair of papers in Immunity and Cell, Ghosh and colleagues show that the canonical NF-kappa B subunits p65 and c-Rel have non-redundant, critical roles in promoting Treg cell development and Oh et al., 2017). Targeting c-Rel blunts Treg cell immunosuppressive activity in the tumor microenvironment and enhances anti-tumor T cell responses (Grinberg-Bleyer et al., 2017).

• 出版日期2017-9-19
• 单位MIT