A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia

作者：Xie Cui; Yao Mian Zhi; Liu Jiang Bo; Xiong Li Kuan^*

来源：Cytokine, 2011, 56(3): 550-559.

DOI：10.1016/j.cyto.2011.09.021

• Preeclampsia
• TNF-alpha
• IL-6
• IL-10
• Meta-analysis

Inflammation may play a major role in the pathogenesis of preeclampsia (PE). In this meta-analysis, we determined whether maternal polymorphisms and serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) were associated with PE. All studies investigating the associations between PE and maternal polymorphisms of TNF-alpha-308G/A, IL-6-174G/C, and IL-10-1082A/G or serum concentrations of TNF-alpha, IL-6, and IL-10 were reviewed. We found that neither maternal TNF-alpha-308G/A (p = 0.86, odds ratio [OR] = 0.98, 95% confidence interval [CI] 0.76-1.25), IL-6 174G/C (p = 0.14, OR = 1.23, 95% CI, 0.93-1.61), nor IL-10-1082A/G (p = 0.72, OR = 1.07, 95% CI, 0.75-1.52) were associated with PE. On the other hand, maternal TNF-alpha (p < 0.00001, weighted mean difference [WMD] = 19.63 pg/ml, 95% CI, 18.54-20.72 pg/ml), IL-6 (p < 0.00001, WMD = 6.58 pg/ml, 95% CI, 5.49-7.67 pg/ml), and IL-10 (p = 0.0005, WMD = 19.30 pg/ml, 95% CI, 8.42-30.17 pg/ml) concentrations were significantly higher in PE patients versus controls. Our findings strengthen the clinical evidence that PE is accompanied by exaggerated inflammatory responses, but do not support TNF-alpha-308G/A, IL-6-174G/C, and IL-10-1082A/G as candidate susceptibility loci in PE.

• 出版日期2011-12