A mathematical model for selective differentiation of neural progenitor cells on micropatterned polymer substrates

作者：Howk Cory L^*; Levine Howard A; Smiley Michael W; Mallapragada Surya K; Nilsen Hamilton Marit; Oh Jisun; Sakaguchi Donald S

来源：Mathematical Biosciences, 2012, 238(2): 65-79.

DOI：10.1016/j.mbs.2012.04.001

• Receptor kinetics
• Interleukin-6 (IL6)
• Adult hippocampal progenitor cells (AHPC)
• Cellular differentiation
• Extended Fourier amplitude sensitivity test (eFAST)

The biological hypothesis that the astrocyte-secreted cytokine, interleukin-6 (IL6), stimulates differentiation of adult rat hippocampal progenitor cells (AHPCs) is considered from a mathematical perspective. The proposed mathematical model includes two different mechanisms for stimulation and is based on mass-action kinetics. Both biological mechanisms involve sequential binding, with one pathway solely utilizing surface receptors while the other pathway also involves soluble receptors. Choosing biologically-reasonable values for parameters, simulations of the mathematical model show good agreement with experimental results. A global sensitivity analysis is also conducted to determine both the most influential and non-influential parameters on cellular differentiation, providing additional insights into the biological mechanisms.

• 出版日期2012-8