Urease and Serine Protease inhibitory alkaloids from Isatis tinctoria

作者：Ahmad Ijaz^*; Fatima Itrat; Afza Nighat; Malik Abdul; Lodhi Muhammad Arif; Choudhary Muhammad Iqbal

来源：Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 23(6): 918-921.

DOI：10.1080/14756360701743580

• Isatis tinctoria
• Brassicaseae
• alkaloids
• urease inhibition
• protease inhibition
• inhibitors

Phytochemical investigations on the alkaloidal fraction of the whole plant of the Isatis tinctoria led to the isolation of the alkaloids 1-6., 3'-Hydroxyepiglucoisatisin (3), Epiglucoisatisin (2) were found to be potent urease inhibitors in a concentration-dependent manner with IC50 values 25.630.74, 37.010.41 and 31.720.93, 47.330.31M against Bacillus pasteurii Jack bean urease, respectively. Compounds 3 and 2 also showed potent inhibitory potential against -chymotrypsin with IC50 values of 23.400.21 and 27.450.23 M, respectively.

• 出版日期2008