A fluorescent surrogate of thymidine in duplex DNA

作者:Mata Guillaume; Schmidt Olivia P; Luedtke Nathan W*
来源:Chemical communications, 2016, 52(25): 4718-4721.
DOI:10.1039/c5cc09552b

摘要

T-DMA is a new fluorescent thymidine mimic composed of 2'-deoxy-uridine fused to dimethylaniline. T-DMA exhibits the same pK(a) and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

  • 出版日期2016