Brain parenchymal TNF-alpha and IL-1 beta induction in experimental pneumococcal meningitis

作者：Izadpanah Kaywan; Freyer Dorette; Weber Joerg R; Braun Johann S^*

来源：Journal of Neuroimmunology, 2014, 276(1-2): 104-111.

DOI：10.1016/j.jneuroim.2014.08.625

• S. pneumoniae
• Pneumococcal cell wall
• Meningitis
• Brain
• TNF-alpha
• IL-1 beta

Triggers of brain inflammation in pneumococcal meningitis are unknown. TNF-alpha and IL-1 beta were upregulated (real time PCR and in situ hybridization) in neurons and astrocytes time-dependently and maximally in the hippocampus during murine pneumococcal meningitis. Upregulation of TNF-alpha and IL-1 beta mRNA in the brain parenchyma was independent of cerebrospinal fluid leukocytosis, pneumococcal pneumolysin and H2O2, but it was potently induced by pneumococcal cell wall (PCW) fragments. Brain TNF-alpha mRNA was downregulated by a matrix metalloproteinases inhibitor. PCW fragments were located in the brain parenchyma. In conclusion, PCW fragments and matrix metalloproteinases trigger cytokine induction in the brain parenchyma during pneumococcal meningitis.

• 出版日期2014-11-15