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摘要
Objective: Age has been shown to be a crucial factor for the EEG and fMRI small-world networks during sleep. However, the characteristics of the age-related network based on the sleep ECG signal and how the network changes during different sleep stages are poorly understood. This study focuses on exploring the age-related scale-free and small-world network properties of the ECG signal from male subjects during distinct sleep stages, including the wakeful (W), light sleep (LS),deep sleep (DS) and rapid eye movement (REM) stages. Approach: The subjects are divided into two age groups: a younger (age <= 40, n = 11) group and an older group (age > 40, n = 25). Main results: For the scale-free network analysis, our results reveal a distinctive pattern of the scale free network topologies between the two age groups, including the mean degree ((d) over bar), the clustering coefficient ((c) over bar), and the path length ((l) over bar) features, such as the slope distribution of (c) over bar in the younger group increased from 1.99 during W to above 2.05 during DS. In addition, the results indicate that the small-world properties can be found across all sleep stages in both age groups. However, the small-world index in the LS and REM stages significantly decreased with age (p = 0.0006 and p = 0.05, respectively). Significance: The comparison analysis result indicates that the network topology variations in the sleep ECG signals are prone to show age-relevant differences that could be used for sleep stage classification and sleep disorder diagnosis.
- 出版日期2018-8
- 单位广西医科大学
