科研之友
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摘要
A new phenylpropanoid glycoside, named alpha-L-rhamnopyranosyl-(1 <-> 2)-beta-D-[4 ''-(8E)-7-(3,4-dihydroxyphenyl)-8-propenoate, 1 ''-O-(7S)-7-(3,4-dihydroxyphenyl)-7-methoxy-ethyl]-glucopyranoside (1), together with nine known compounds (2-10) were isolated from the active fraction (n-Butanol fraction) of Gynura cusimbua for the first time. The known compounds (2-10) were identified as phenylpropanoid glycosides on the basis of extensive spectral data and references. The antiangiogenic activities of compounds (1-10) were evaluated by MTT assay on HUVECs and wild-type zebrafish in vivo model assay. As a result, compounds 1, 6, 7, 8 and 10 exhibited certain antiangiogenic activities. [GRAPHICS] .
