Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study

作者：Labudda Kirsten^*; Brand Matthias; Mertens Markus; Ebner Alois; Markowitsch Hans J; Woermann Friedrich G

来源：Neurocase, 2010, 16(1): 59-73.

DOI：10.1080/13554790903329125

• Frontal lobe
• Malformation of cortical development
• Congenital lesion
• fMRI
• Neuropsychology
• Decision making

We investigated the impact of a congenital prefrontal lesion and its resection on decision making under risk and under ambiguity in a patient with right mediofrontal cortical dysplasia. Both kinds of decision making are normally associated with the medial prefrontal cortex. We additionally studied pre- and postsurgical fMRI activations when processing information relevant for risky decision making. Results indicate selective impairments of ambiguous decision making pre- and postsurgically. Decision making under risk was intact. In contrast to healthy subjects the patient exhibited no activation within the dysplastic anterior cingulate cortex but left-sided orbitofrontal activation on the fMRI task suggesting early reorganization processes.

• 出版日期2010