Diselaginellin B, an Unusual Dimeric Molecule from Selaginella pulvinata, Inhibited Metastasis and Induced Apoptosis of SMMC-7721 Human Hepatocellular Carcinoma Cells

作者：Cao, Yuan; Zha, Ming; Zhu, Yue; Zhu, Zhen-Hua; Oberer, Lukas; Duan, Jin-Ao^*

来源：Journal of Natural Products, 2017, 80(12): 3152-3159.

DOI：10.1021/acs.jnatprod.7b00404

• ALPHA-KETOGLUTARATE DEHYDROGENASE
• CYCLOOXYGENASE-2 INHIBITORS
• CARCINOEMBRYONIC ANTIGEN
• COX-2 INHIBITOR
• GENE SIGNATURE
• TAMARISCINA
• CANCER
• DERIVATIVES
• EXPRESSION
• PROLIFERATION

Two new unusual dimeric selaginellins, diselaginellins A and B (1 and 2), along with two known derivatives, selaginellin (3) and selaginellin B (4), were isolated from Selaginella pulvinata. Their structures were elucidated by extensive NMR and high-resolution ESIMS data analysis. Compound 2 displayed apoptosis-inducing and antimetastatic activities against the human hepatocellular carcinoma cell line SMMC-7721. A microarray analysis revealed that genes related to metabolism, angiogenesis, and metastasis were altered by 2. The up-and down-regulation of the mRNA levels of related genes was confirmed by RT-qPCR Metabolism mo' metastasis inhibition might be the mechanisms of the antitumor properties of chselagmellin B (2).

• 出版日期2017-12
• 单位南京中医药大学