Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages

作者：May Petra; Bock Hans H; Nofer Jerzy Roch^*

来源：Cell and Tissue Research, 2013, 354(3): 887-889.

DOI：10.1007/s00441-013-1699-2

• Low density receptor-related protein 1
• Anti-inflammatory activity
• Macrophage
• Mouse

We have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 (%26quot;classic%26quot;) to M2 (%26quot;alternative%26quot;) in a process involving signaling via low-density lipoprotein receptor (LDLR) family members including the VLDL receptor (VLDLR) or apoE receptor-2 (apoER2). The present study was undertaken to investigate whether LDLR-related protein 1 (LRP-1), another member of the LDLR family and a ubiquitously expressed multifunctional cell surface receptor, modulates M1 -%26gt; M2 conversion in murine macrophages. We investigate bone marrow or peritoneal macrophages isolated from wild-type C57/Bl6 mice or mice with conditional inactivation of the LRP-1 gene in the myeloid lineage for the expression of polarization markers. Our results suggest that the deficiency of LRP-1 down-regulates M2 marker expression in macrophages, while enhancing the macrophage response to M1 stimuli. To our knowledge, this is the first demonstration that LRP-1 affects macrophage polarization and promotes the development of an anti-inflammatory M2 functional phenotype.

• 出版日期2013-12