Amphiphilic block copolymer self-assemblies of poly(NVP)-b-poly(MDO-co-vinyl esters): Tunable dimensions and functionalities

作者：Hedir Guillaume G; Pitto Barry A; Dove Andrew P; O'Reilly Rachel K^*

来源：Journal of Polymer Science Part A: Polymer Chemistry , 2015, 53(23): 2699-2710.

DOI：10.1002/pola.27915

• block copolymers
• cyclic ketene acetal
• degradable
• nanoparticles
• self-assembly

Functional, degradable polymers were synthesized via the copolymerization of vinyl acetate (VAc) and 2-methylene-1,3-dioxepane (MDO) using a macro-xanthate CTA, poly(N-vinylpyrrolidone), resulting in the formation of amphiphilic block copolymers of poly(NVP)-b-poly(MDO-co-VAc). The behavior of the block copolymers in water was investigated and resulted in the formation of self-assembled nanoparticles containing a hydrophobic core and a hydrophilic corona. The size of the resultant nanoparticles was able to be tuned with variation of the hydrophilic and hydrophobic segments of the core and corona by changing the incorporation of the macro-CTA as well as the monomer composition in the copolymers, as observed by Dynamic Light Scattering, Static Light Scattering, and Transmission Electron Microscopy analyses. The concept was further applied to a VAc derivative monomer, vinyl bromobutanoate, to incorporate further functionalities such as fluorescent dithiomaleimide groups throughout the polymer backbone using azidation and click chemistry as postpolymerization tools to create fluorescently labeled nanoparticles.

• 出版日期2015-12-1