Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the FLT3-ITD Mutation

作者：Isshiki Yusuke; Ohwada Chikako; Togasaki Emi; Shimizu Ryoh; Hasegawa Nagisa; Yamazaki Atsuko; Sugita Yasumasa; Kawaguchi Takeharu; Tsukamoto Shokichi; Sakai Shio; Takeda Yusuke; Takeuchi Masahiro; Sakaida Emiko; Shimizu Naomi; Ota Satoshi; Yokote Koutaro; Iseki Tohru; Nakaseko Chiaki^*

来源：Internal Medicine, 2014, 53(11): 1159-1164.

DOI：10.2169/internalmedicine.53.1137

• myeloid sarcoma
• granulocytic sarcoma
• acute myeloid leukemia
• CD25
• FLT3-ITD
• soluble interleukin-2 receptor

Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.

• 出版日期2014