Nanoradiopharmaceuticals for Bone Cancer Metastasis Imaging

作者：Coelho Bianca Feliciano; Albernaz Marta de Souza; Iscaife Alexandre; Moreira Leite Katia Ramos; Junqueira Mara de Souza; Bernardes Emerson Soares; da Silva Emerson Oliveira; Santos Oliveira Ralph^*

来源：Current Cancer Drug Targets, 2015, 15(5): 445-449.

DOI：10.2174/1568009615666150407125020

• Bone
• nanotechnology
• oncology
• radiopharmaceuticals

Drug delivery systems are under intense investigation all around the world, especially in oncology research. Indeed, in some cases, like bone metastasis, nanodrugs may represent the last and best choice for both treatment and imaging of early cancer foci. Nuclear medicine has been using MDP labelled with 99mTc as radiopharmaceuticals for many years; however, their use as nanoradiopharmaceuticals is very innovative and creates a new way to establish radiopharmacy in this new scenario offered by nanotechnology. In this study we developed and tested nano-MDP-labelled with 99mTc in rats induced with bone cancer metastasis and the results showed that it may work in patients. However, some further experiments are required in order to initiate protocols in humans.

• 出版日期2015