Actinic damage on the back is significantly determined by MC1R variants and previous sun exposure compared with other body sites in a multivariate analysis

作者：Wendt J; Rauscher S; Burgstaller Muehlbacher S; Roka F; Fae I; Fischer G; Pehamberger H; Okamoto I^*

来源：British Journal of Dermatology, 2014, 171(3): 622-630.

DOI：10.1111/bjd.12994

Background Only recently, site dependent associations of actiniic damage with mela Emma were identified in our study population. Objectives To elucidate the diverse aetiologies for actinic damage at different hotly sites. %26lt;br%26gt;Methods We performed multivariate logistic regression analyses to identify independent risk factors for actinic damage on the face, hands and the back in 2112 participants of central European origin. Results For actinic damage on the face, age was the only risk factor that remained consistently significant in a multivariate analysis, whereas actinic damage on the back was predominantly associated with number of sunburns, freckles in child-hood, holiday weeks and male sex. Moreover, we icientifieci a particular significance of MC IR variants arid dorsal actinic skin damage. %26lt;br%26gt;Conclusions The particular effect of MC1R variants and sun exposure during recreational time on dorsal actinic damage indicates that actinic damage on the back is more informative regarding susceptibility to sunlight and past sun exposure associated with melanoma risk.

• 出版日期2014-9