Al(OTf)(3) as a new efficient catalyst for the direct nucleophilic substitution of ferrocenyl alcohol substrates. Convenient preparation of ferrocenyl-PEG compounds

作者：Allali Naoual; Mamane Victor^*

来源：Tetrahedron Letters, 2012, 53(21): 2604-2607.

DOI：10.1016/j.tetlet.2012.03.042

• Nucleophilic substitution
• Ferrocene
• Aluminium triflate
• PEG
• Catalysis

The use of Al(OTf)(3) as a new efficient catalyst for the direct nucleophilic substitution of the hydroxy group of ferrocenyl alcohols is described. This catalyst, originally developed for the mono-substitution of ethylene glycol nucleophiles of different length has shown a high activity with other carbon-, nitrogen-, and sulfur-based nucleophiles. In all the studied cases, no more than 1 mol % of catalyst was needed to allow fast and clean reactions.

• 出版日期2012-5-23