New genes involved in hepatic steatosis

作者：Lou Bonafonte Jose M; Arnal Carmen; Osada Jesus^*

来源：Current Opinion in Lipidology, 2011, 22(3): 159-164.

DOI：10.1097/MOL.0b013e3283462288

• hepatic steatosis
• lipid droplets
• lipid metabolism
• nonalcoholic fatty liver disease

Purpose of review
To summarize currently available information about the mechanisms involved in liver fat accumulation.
Recent findings
The contribution of functional genomics approaches, such as those represented by high-throughput analysis and genetically modified mice, may envision a complex network involving fatty acid, triglyceride and phospholipid metabolisms and lipid droplet dynamics. Likewise, it may pose an exquisite regulation exerted through insulin, glucocorticoids, thyroid hormones, transcription factors and microRNAs, orchestrated with sexual differences and able to respond to environmental factors such as nutritional or viral influences among others.
Summary
The information gathered will facilitate further research to complete gaps of interacting pieces among regulators and new contributing agents emerging from high-throughput analyses. With this new paradigm, new biomarkers able to discriminate the progression of hepatic steatosis into human steatohepatitis will eventually emerge, and hopefully new therapeutic approaches will be developed.

• 出版日期2011-6