Modification of Polysulfones by Click Chemistry: Amphiphilic Graft Copolymers and Their Protein Adsorption and Cell Adhesion Properties

作者：Yilmaz Gorkem; Toiserkani Hojjat; Demirkol Dilek Odaci; Sakarya Serhan; Timur Suna^*; Yagci Yusuf; Torun Lokman

来源：Journal of Polymer Science Part A: Polymer Chemistry , 2011, 49(1): 110-117.

DOI：10.1002/pola.24424

• amphiphilic polymers
• click chemistry
• functionalization of polymers
• graft copolymers
• poly(ether sulfones)

Well-defined amphiphilic graft copolymer with hydrophobic polysulfone (PSU) backbone and hydrophilic poly(acrylic acid) (PAA) side chains were synthesized and characterized. For this purpose, commercially available PSU was converted to azido-functionalized polymer (PSU-N(3)) by successive chloromethylation and azidation processes. Independently, poly(tert-butyl acrylate) (PtBA) with an alkyne-end-group is obtained by using suitable initiator in atom transfer radical polymerization (ATRP). Then, this polymer was successfully grafted onto PSU-N3 by click chemistry to yield polysulfone-graft-poly(tert-butyl acrylate), (PSU-g-PtBA). Finally, amphiphilic polysulfone-graft-poly(acrylic acid), (PSU-g-PAA), membranes were obtained by hydrolyzing precursor the PSU-g-PtBA membranes in trifluoroacetic acid. The final polymer and intermediates at various stages were characterized by (1)H NMR, FTIR, GPC, and SEM analyses. Protein adsorption and eukaryotic and prokaryotic cell adhesion on PSU-g-PAA were studied and compared to those of PSU-g-PtBA and unmodified PSU.

• 出版日期2011-1-1