科研之友
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摘要
Efforts toward a stereoselective synthetic route to (+)-lactacystin based on organocatalytic transformations and intramolecular amino hydroxylation for creating the tetrasubstituted stereogenic center are described. Tethered aminohydroxylation of an allylic carbamate following Donohue's protocol affords a regioisomeric amino alcohol derivative, while Lewis acid promoted epoxide opening by a trichloroacetimidate yields a tetrahydrofuran derivative.
- 出版日期2014-8
