Development of an AIDS vaccine using Sendai virus vectors

作者：Ishii Hiroshi; Matano Tetsuro^*

来源：Vaccine, 2015, 33(45): 6061-6065.

DOI：10.1016/j.vaccine.2015.06.114

• AIDS vaccine
• Sendai virus vector
• HIV
• SIV

Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.

• 出版日期2015-11-9
• 单位河北医科大学