An organocatalytic synthesis of N-sulfonyl imines using chloramine-T in aqueous medium

作者：Chawla Ruchi; Singh Atul K; Yadav Lal Dhar S^*

来源：Tetrahedron Letters, 2014, 55(25): 3553-3556.

DOI：10.1016/j.tetlet.2014.04.096

• Aldehydes
• Chloramine-T
• N-Sulfonyl imines
• Aqueous medium
• Organocatalysis

N-Sulfonyl imines have been synthesized in good to excellent yields from aldehydes and chloramine-T using proline as an organocatalyst in aqueous medium at ambient temperature. The protocol is applicable to a wide range of aldehydes, especially enals exhibit remarkable efficiency in the reaction. The reaction presumably occurs via iminium activation and opens new avenues for the synthesis of N-sulfonyl imines under environmentally benign and mild conditions.

• 出版日期2014-6-18