科研之友
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摘要
The study-objective was to measure the effect of weight and growth related parameters on the risk of development of Canine Hip Dysplasia (CHD) The hypothesis was that heavy and fast growing dogs of large sized breeds were at increased risk of development of CHD compared to lighter and slower growing dogs A prospective cohort study was conducted among dogs of four large breeds Newfoundland (NF) Leonberger (LEO) Labrador retriever (LR) and Irish wolfhound (IW) The dogs were privately owned with individualized nutrition and environment and they were followed from birth and throughout the growth period until the official screening for CHD was performed The study sample consisted of 501 dogs from 103 litters with the breed distribution 125 NF 180 LEO 133 LR and 63 IW Because the dogs were clustered in litters a multivariable random effects logistic regression model was used to assess statistically significant growth-related risk factors for CHD The estimated incidence risk of CHD was 36% in NF 25% in LEO 20% in LR and 10% in IW Based upon the final multilevel model it appears that the odds of CHD among both LR and IW (odds ratio (OR) 0 22) are about one-fifth of the odds for NF The odds for LEO (OR 0 60) are not significantly different from NF There appeared to be an inverse relationship between body weight at 3 months of age and odds of CHD with an OR of 089 (P= 0 044) The degree of clustering at the litter-level was high (22 6%) and highly significant (P< 0 001) Findings failed to support the hypothesis that heavy and fast growing dogs from four large sized breeds were at increased risk for development of CHD There might be other unmeasured environmental
- 出版日期2010-12-1
