A recurrence-free survivor with chemotherapy-refractory small cell lung cancer after pneumonectomy A case report and review of the literature

作者：Pan Yong; Kong Feng-Wei; Wang Heng; Wang Xiang; Zhang Hui; Wu Wen-Bin; Zhang Miao^*

来源：Medicine, 2017, 96(47): e8922.

DOI：10.1097/MD.0000000000008922

• apatinib
• salvage surgery
• small cell lung cancer (SCLC)
• targeted therapy

Rationale: The optimal therapeutic regimen for chemotherapy-refractory and node-positive small-cell lung cancer (SCLC) is criticizable for the lack of evidence.
Patient concerns: A patient with locally advanced SCLC was insensitive to the first-line chemotherapy of etoposide, irinotecan, and cisplatin.
Diagnoses: The patient was diagnosed as SCLC with mediastinal lymph node metastasis by pathological staining.
Interventions: Salvage pneumonectomy and systematic lymph node dissection combined with oral apatinib and mediastinal radiotherapy were performed for him.
Outcomes: The patient survived for more than 2 years without recurrence after the operation and adjuvant therapy.
Lessons: For patients with chemotherapy-resistant but resectable SCLC, a timely resection combined with postoperative radiotherapy and apatinib might be effective.

• 出版日期2017-11
• 单位东南大学