Abdominal Obesity and Age-related Macular Degeneration

作者：Adams Madeleine K M^*; Simpson Julie A; Aung Khin Zaw; Makeyeva Galina A; Giles Graham G; English Dallas R; Hopper John; Guymer Robyn H; Baird Paul N; Robman Liubov D

来源：American Journal of Epidemiology, 2011, 173(11): 1246-1255.

DOI：10.1093/aje/kwr005

• aging
• macular degeneration
• obesity

Evidence for an association between age-related macular degeneration (AMD) and obesity is inconsistent. The authors examined associations between adiposity and AMD prevalence using 21,287 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). For men, each increase of 0.1 in waist/hip ratio (similar to 1 standard deviation) was associated with a 13% increase in the odds of early AMD (odds ratio - 1.13, 95% confidence interval: 1.01, 1.26; P = 0.03) and a 75% increase in the odds of late AMD (odds ratio = 1.75, 95% confidence interval: 1.11, 2.76; P = 0.02). No other adiposity measure was associated with early AMD for men. Smoking status modified the relation between waist/hip ratio and early AMD (P = 0.05), with no association for former smokers. For women, there were inverse associations with early AMD for all adiposity measures (odds ratios = 0.89-0.93; P = 0.002-0.02), but no associations were observed for late AMD. This study confirms abdominal obesity as an AMD risk factor for men despite a survivorship effect from competing risks in morbidity and mortality. The inverse associations for women may reflect weaker true positive associations with AMD that are insufficient to overcome the survivorship effect. New data are provided on complex interactions between environmental exposures and AMD risk.

• 出版日期2011-6-1