科研之友
微信
新浪微博
Facebook
分享链接
摘要
A sensitive electrochemical sensor based on beta-cyclodextrin/Nafion (R)/poly(3,4-ethylene-dioxythiophene) nanocomposite modified gold electrode Au/PEDOT/NF/CD was fabricated for the determination of paracetamol ACOP in presence of interference compounds. Au/PEDOT/NF/CD showed an excellent electrocatalytic synergism between its components for the electrooxidation of ACOP. Conductive PEDOT polymer film acts as an electron mediator with a rich electron cloud. Furthermore nafion improves the electrical conductivity of the composite as well it works as suitable layer for the formation of the CD film over it due to its good adhesion at the polymer surface and good film forming ability. By the modification of Au/PEDOT/NF with CD film, enhanced charge transfer kinetics and improved oxidation current for ACOP were obtained. A supramolecular host-guest inclusion complex is formed between beta-CD and ACOP via electrostatic, inclusion interactions and hydrogen bonds formation. The formation of such complex resulted in selective advantage and enhancement of the charge transfer properties of ACOP. ACOP molecules penetrate into the less polar cavity of beta-CD and ACOP: CD inclusion complex was formed which further resulted in significant increase in oxidation signal of ACOP. Under optimized conditions a linear calibration curve was obtained for the determination of ACOP in urine within the range 3-300 mu mol L-1, with a correlation coefficient of 0.9958 and detection limit of 36.1nmol L-1. Simultaneous determinations of ACOP and epinephrine (EP), ACOP and norepinephrine (NE), ACOP, DA and AA and ACOP, EP and AA were achieved at the modified sensor with high resolution and good potential peak separation.
- 出版日期2015-2
