A significant correlation between the plasma levels of coenzyme Q10 and vitamin B-6 and a reduced risk of coronary artery disease

作者：Lee Bor Jen; Yen Chi Hua; Hsu Hui Chen; Lin Jui Yuan; Hsia Simon; Lin Ping Ting^*

来源：Nutrition Research, 2012, 32(10): 751-756.

DOI：10.1016/j.nutres.2012.09.003

• Coenzyme Q10
• Vitamin B-6
• Coronary artery disease
• Case-control study
• Nutrition

Coronary artery disease (CAD) is the leading cause of death worldwide. The purpose of this study was to investigate the relationship between plasma levels of coenzyme Q10 and vitamin 8-6 and the risk of CAD. Patients with at least 50% stenosis of one major coronary artery identified by cardiac catheterization were assigned to the case group (n = 45). The control group (n = 89) comprised healthy individuals with normal blood biochemistry. The plasma concentrations of coenzyme Q10 and vitamin 8-6 (pyridoxal 5%26apos;-phosphate) and the lipid profiles of the participants were measured. Subjects with CAD had significantly lower plasma levels of coenzyme Q10 and vitamin 8-6 compared to the control group. The plasma coenzyme Q10 concentration (beta = 1.06, P = .02) and the ratio of coenzyme Q10 to total cholesterol (beta = .28, P = .01) were positively correlated with vitamin 8-6 status. Subjects with higher coenzyme Q10 concentration (%26gt;= 516.0 nmol/L) had a significantly lower risk of CAD, even after adjusting for the risk factors for CAD. Subjects with higher pyridoxal 5%26apos;-phosphate concentration (%26gt;= 59.7 nmol/L) also had a significantly lower risk of CAD, but the relationship lost its statistical significance after adjusting for the risk factors of CAD. There was a significant correlation between the plasma levels of coenzyme Q10 and vitamin 8-6 and a reduced risk of CAD. Further study is needed to examine the benefits of administering coenzyme Q10 in combination with vitamin 8-6 to CAD patients, especially those with low coenzyme Q10 level.

• 出版日期2012-10