Active and placebo transcranial magnetic stimulation effects on external and internal auditory hallucinations of schizophrenia

作者：Paillere Martinot, M L^*; Galinowski, A; Plaze, M; Andoh, J; Bartres Faz, D; Bellivier, F; Lefaucheur, J P; Riviere, D; Gallarda, T; Martinot, J L; Artiges, E

来源：Acta Psychiatrica Scandinavica, 2017, 135(3): 228-238.

DOI：10.1111/acps.12680

• auditory hallucinations
• functional magnetic resonance imaging
• randomized placebo-controlled trial
• repetitive transcranial magnetic stimulation
• schizophrenia

Objective: Repetitive transcranial magnetic stimulation (rTMS) over the left temporo-parietal region has been proposed as a treatment for resistant auditory verbal hallucinations (AVH), but which patients are more likely to benefit from rTMS is still unclear. This study sought to assess the effects of rTMS on AVH, with a focus on hallucination phenomenology.
Method: Twenty-seven patients with schizophrenia and medicationresistant AVH participated to a randomized, double-blind, placebocontrolled, add-on rTMS study. The stimulation targeted a languageperception area individually determined using functional magnetic resonance imaging and a language recognition task. AVH were assessed using the hallucination subscale of the Scale for the Assessment of Positive Symptoms (SAPS). The spatial location of AVH was assessed using the Psychotic Symptom Rating Scales.
Results: A significant improvement in SAPS hallucination subscale score was observed in both actively treated and placebo-treated groups with no difference between both modalities. Patients with external AVH were significantly more improved than patients with internal AVH, with both modalities.
Conclusions: A marked placebo effect of rTMS was observed in patients with resistant AVH. Patients with prominent external AVH may be more likely to benefit from both active and placebo interventions. Cortical effects related to non-magnetic stimulation of the auditory cortex are suggested.

• 出版日期2017-3
• 单位上海市精神卫生中心; 中国地震局