Angiogenesis and parasitic helminth-associated neovascularization

作者：Dennis Roger D^*; Schubert Uwe; Bauer Christian

来源：Parasitology, 2011, 138(4): 426-439.

DOI：10.1017/S0031182010001642

• angiogenesis
• angiogenic switch
• angiogenic growth factor
• VEGF
• parasitic helminth-associated neovascularization
• Cestoda
• Nematoda
• Trematoda

Successful metazoan parasitism, among many other factors, requires a supply of nutrients and the removal of waste products. There is a prerequisite for a parasite-defined vasculature. The angiogenic mechanism(s) involved presumably depend on the characteristics of the tissue-and vascular system-dwelling, parasitic helminths. Simplistically, 2 possibilities or a combination of both have been considered in this review. The multifactorial induction of parasitic helminth-associated neovascularization could arise through, either a host-, a parasite-or a host-/parasite-dependent, angiogenic switch. Most studies appear to support the first and third hypotheses, but evidence exists for the intrahepatic cestode Echinococcus multilocularis, the free-living nematode Caenorhabditis elegans and the intravascular trematode Schistosoma mansoni for the second inference. In contrast, the nematode anti-coagulant protein NAPc2 from adult Ancylostoma caninum is also an anti-angiogenic factor.

• 出版日期2011-4