Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques

作者：Heo Hye Young; Zhang Yi; Lee Dong Hoon; Jiang Shanshan; Zhao Xuna; Zhou Jinyuan^*

来源：Magnetic Resonance in Medicine, 2017, 77(2): 779-786.

DOI：10.1002/mrm.26141

• CEST
• APT
• brain tumor
• compressed sensing
• SENSE

PurposeTo evaluate the feasibility of accelerated chemical-exchange-saturation-transfer (CEST) imaging using a combination of compressed sensing (CS) and sensitivity encoding (SENSE) at 3 Tesla.
Theory and MethodsTwo healthy volunteers and six high-grade glioma patients were recruited. Raw CEST image k-space data were acquired (with varied radiofrequency saturation power levels for the healthy volunteer study), and a sequential CS and SENSE reconstruction (CS-SENSE) was assessed. The MTRasym(3.5ppm) signals were compared with varied CS-SENSE acceleration factors.
ResultsIn the healthy volunteer study, a CS-SENSE acceleration factor of R=2x2 (CSxSENSE) was achieved without compromising the reconstructed MTRasym(3.5ppm) image quality. The MTRasym(3.5ppm) signals obtained from the CS-SENSE reconstruction with R=2x2 were well preserved compared with the reference image (R=2 for only SENSE). In the glioma patient study, the MTRasym(3.5ppm) signals were significantly higher in the tumor region (Gd-enhancing tumor core) than in the normal-appearing white matter (P<0.001). There was no significant MTRasym(3.5ppm) difference between the reference image and CS-SENSE-reconstructed image in the acceleration factor of R=2x2.
ConclusionCombining the SENSE technique with CS (R=2x2) enables considerable acceleration of CEST image acquisition and potentially has a wide range of clinical applications. Magn Reson Med 77:779-786, 2017.

• 出版日期2017-2