Microwave-assisted deuterium exchange: The convenient preparation of isotopically labelled analogues for stable isotope dilution analysis of volatile wine phenols

作者：Crump Anna M; Sefton Mark A; Wilkinson Kerry L^*

来源：Food Chemistry, 2014, 162: 261-263.

DOI：10.1016/j.foodchem.2014.04.051

• Volatile phenols
• Microwave-assisted deuterium exchange
• Isotope labelling

This study reports the convenient, low cost, one-step synthesis of labelled analogues of six volatile phenols, guaiacol, 4-methylguaiacol, 4-ethylguaiacol, 4-ethylphenol, eugenol and vanillin, using microwave-assisted deuterium exchange, for use as internal standards for stable isotope dilution analysis. The current method improves on previous strategies in that it enables incorporation of deuterium atoms on the aromatic ring, thereby ensuring retention of the isotope label during mass spectrometry fragmentation. When used as standards for SIDA, these labelled volatile phenols will improve the accuracy and reproducibility of quantitative food and beverage analysis.

• 出版日期2014-11-1