Ag/SiO2 as a recyclable catalyst for the facile green synthesis of 3-methyl-4-(phenyl)methylene-isoxazole-5(4H)-ones

作者：Maddila Surya Narayana; Maddila Suresh; van Zyl Werner E; Jonnalagadda Sreekantha B^*

来源：Research on Chemical Intermediates, 2016, 42(3): 2553-2566.

DOI：10.1007/s11164-015-2167-2

• Green synthesis
• Heterogeneous catalyst
• Isoxazoles
• Ag/SiO2
• One-pot reaction

An efficient and facile green method for synthesis of 3-methyl-4-(phenyl)methylene-isoxazole-5(4H)-one (4a-m) via room temperature reaction of hydroxylamine, ethylacetoacetate and substituted aromatic aldehydes is designed, using Ag/SiO2 as catalyst with water as solvent. This protocol offers several advantages, such as it being a benign, energy conserving and eco-friendly reaction with products obtained in excellent yields (88-93 %). The reaction requires relatively short reaction times (< 1 h), a simple workup procedure with good atom efficiency and easily recoverable catalyst. The heterogeneous catalyst, Ag/SiO2, was fully characterized and is reusable without loss of activity for up to seven cycles with marginal activity loss.

• 出版日期2016-3