科研之友
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摘要
This paper describes two rapid, sensitive and specific methods for determination of olanzapine in pharmaceutical preparations by square wave voltammetry (SWV) and differential pulse voltammetric (DPV). The proposed methods were based on electrochemical oxidation of olanzapine on glassy carbon electrode in solution containing 0.04 M Britton-Robinson buffer of pH 1.65. The well-defined an oxidation peak was observed at 1.06 V. The calibration curves were linear for olanzapine at the concentration range of 0.5-7 mu g/mL for SWV and DPV methods, respectively. Intra-and inter-day precision values for olanzapine were less than 5.21, and accuracy (relative error) was better than 4.33%. The mean recovery of olanzapine was 99.7% for pharmaceutical preparation. The developed methods were applied to a pharmaceutical preparation (Ollafax) as tablet form which do not require any preliminary separation or treatment of the samples. No interference excipient was found at the selected assay conditions. The proposed methods is highly sensitive, precise and accurate and can be used for the reliable quantitation of olanzapine in pharmaceutical preparation.
- 出版日期2018
